Should a Megaroad-01 project come forth, I anticipate that half of the people here will be happy, while the other half bemoans the trashing of their cherished original characters. Loudly and often. And that's before even considering whether the production would be good or not. So I personally would prefer that Megaroad-01 remains an unsolved mystery.
When we last saw the original triangle, they were all relatively young, and much could have happened to them in the meantime (assuming that whatever story is being told is set contemporaneously with the main Macross timeline or even around the "Lady M transmission" period). Any significant differences in the character dynamic would easily be explained that way. It would probably be jarring for some viewers; it worked out for Max and Milia in M7 because they were supporting cast, while the original triangle helped to define SDFM. The writing of the characters would benefit from 35 years of updating; series Hikaru did get hit with the stupid stick really hard after Episode 27, and SDFM's character interactions can feel charmingly antiquated these days.
But people hate change. There would be an urge to revisit the love triangle after 50+ years, which I think would turn out to be incredibly trite. Carrying a torch for fifty years is romantic and all, but also really boring.
The less-risky plan is to take the M7 route and focus on new characters, moving HMM to the background, but they'd STILL end up drawing all the attention even if the new characters were amazing.
But they can't all be killed off, people won't care about the new series then and/or will be incredibly angry.
So if there's a new series, Hikaru should already be dead before it starts. It would bypass the tragic death of Arihiro Hase, and would give Misa and Minmay a reason for conflict. Even if they all bonded and mended fences after Flashback 2012, removing one side of the triangle is a very plausible source of conflict.
My idea would make a lot of people flip tables and not want to watch, so I'll return to my initial statement and say that Megaroad-01 should never be seen again.