Or rather, Simon becomes the Spiral Nemesis and all other Spiral races will converge to destroy him along with earth because his existence will end the universe.
Generally the repeating theme here is Spiral beings (humans, sentient beings) are greedy and will always seek to achieve higher goals and greatness and thus, evolution. I'm not sure about this but I think the idea is if spiral beings evolve to their limit, their passionate goals of grandeur will consume themselves and destroy the universe. This ultimate evolution is ironically called the Spiral Nemesis. Yeah very Atlantis-like. The anti-spirals stopped their evolution and took it upon themselves to keep everyone at status quo, so nobody becomes the Spiral Nemesis....which ironically was exactly what Lord Genome was doing by keeping the human numbers on the planet low.
So i guess generally the message conveyed here is.....kick reason to the curb....don't let others tell you what's good for you. Fight them if you need to.