Concerning the guitar interface. I think it could be fairly reasonable to control a fighter through an odd interface like say a guitar, instead of the normal control stick and throttle. As long as the guitar has the same number of possible input options as the regular setup, sure why not. It guess could work, but I'd find it silly anyway. What I don't believe would work, is playing a song on said guitar, while still making the fighter do what you want. Given that the guitar controls the plane, playing a song on it would be nothing short of suicidal (maybe not in space, but certainly within gravity or in proximity to things you can crash into).
You'd have to choose basicly. Steer the plane in a way you have control over it while producing random noise from your guitar interface. Or die a horrible death as the plane spins out of control from the random input you're giving it as you're playing your latest hit single...