No, it should run fine, unless you got some really old school crap cd rom You'll need plugins for the emu to run tho, just be sure to configure them b4 you play. Here's a link http://www.zophar.net/utilities/psplugins.html
I don't use ePSXe alot, but in VF-X2 the video and sound lags a bit in the intro. Gameplay is fine tho (graphics are alot better than on a real PSX =) The only other game I've been playing on ePSXe is Castlevania: Symphony of the Night, and that runs perfectly